Screening the seventies: Representations of the 1970s in British film and television

This thesis maps how the 1970s has been constructed in twenty-first century British culture. It analyses representations of the decade in British film and television made between the years 2002 and 2014. The thesis suggests that the repeated audio-visual return to the 1970s in contemporary Britain entails a recognition of the decade as a transitional period that saw the arrival of the changes that define our world today. It demonstrates how the manner in which the 1970s is remembered and understood is of considerable significance to how we understand the present. It also argues that the complexities and nuances of these representations have been largely unexplored. The thesis has four chapters. Chapter One situates the detailed textual analysis that follows within the broader concerns of the thesis and existing scholarly literature. This first chapter develops the contours of the thesis’ argument and outlines the originality of the project. It argues that the nuance and complexity of the relationship between past and present in audio-visual histories is underexplored and subsumed in dichotomies that argue for their ‘progressive’ or ‘reactionary’ potential. This argument is developed through the proposition that insufficient attention has been paid to the formal, stylistic and narrational strategies used to construct the past on screen. The chapter proposes an approach which brings questions of tone, style, and point of view to the forefront of analysis. Chapter Two groups generic engagements with the 1970s, the spy thriller Tinker Tailor Soldier Spy (Tomas Alfredson, 2011), the conspiracy thriller Red Riding (Channel 4, 2009), and the retro police procedural Life on Mars (BBC, 2006-8). The chapter considers how these texts interweave the historic with the generic. It also affirms the importance of tone in considering how the past is shaped in the present, as the case studies are viewed in conjunction with writing on melancholia and mourning. Chapter Three challenges the usual definitions of British cinema by including texts that are set in Northern Ireland. It explores difficult and traumatic associations of the 1970s in representations of the ‘Troubles’ on screen in Five Minutes of Heaven (Oliver Hirschbiegel, 2009), Shadow Dancer (James Marsh, 2012) and ’71 (Yann Demange, 2014). Chapter Four considers questions of identity and consumerism by looking at two films that engage with music and youth culture in locations far from the metropolitan core, Anita & Me (Metin Hüseyin, 2002) and Good Vibrations (Lisa Barros D’Sa, Glenn Leyburn, 2012). Both films are marked as autobiographical or semi-autobiographical in nature and the chapter focuses on point of view and questions of retro and nostalgia. It explores how the texts facilitate a different relationship between past, present and future than previous case studies. The thesis thus brings together a range of films and television programmes set in the 1970s, and through detailed textual analysis pays attention to questions of tone and the articulation of temporality in history. It demonstrates that the 1970s are being made and remade with considerable sophistication and nuance in twenty-first century texts. Attention to the tone and point of view of these texts gives insight into the struggles over the history of the present

A Guide To How Business Schools Can Develop Academic Staff To Engage With Smes

The impetus for business schools to work with small firms is growing. At over 98% of the UK business population, it is essential that our education and research are relevant and useful to Small and Medium-Sized Enterprises (SMEs) and support their growth, sustainability, and resilience. The profound disruption of the global Covid-19 pandemic has consolidated this push to help bolster our small business population, as well as having profound impacts on the number of new small firms, their business models, products, and their digital transformation.Yet the take up of business school programmes among SMEs is historically low compared with larger companies. Leadership skills gaps in small firms persist, despite UK and devolved governments’ funding and focus.The Chartered Association of Business Schools (Chartered ABS) therefore invited academics from business schools around the UK to explore how schools can develop their staff to engage with SMEs. The working group’s focus was on identifying interventions to increase the amount of business school engagement with SMEs, while examining the barriers and how some schools have overcome them. It also explored enablers of engagement and based its recommendations around practice in Small Business Charter (SBC) awarded schools, and insights gained from relevant literature and policy documents. This working group has developed this report before and during the global pandemic, which has also hugely affected universities and business schools themselves.This document is designed primarily to be a practical aid to decision making for business school leaders, although it may be of interest to a wider stakeholder group, for example business engagement leads in universities, and the Small Business Charter Board.Following secondary research and case study development, and in acknowledgement of changing landscapes for both small firms and universities, recommendations have been proposed, which, for the most part, map onto the identified barriers and challenges. These recommendations are not Covid-specific, but have been evaluated in the light of the seismic changes to both small firms and business schools during this period, and are designed to support resilience and deeper collaborative relationships for recovery and growth. The significant list of recommendations is not proposed to be undertaken in its entirety; it is anticipated that readers will use this document as a resource and may well find some sections more relevant and useful than others. It is also likely that there are other staff development approaches which have proved successful to universities which are not captured here – the working group welcomes contributions which add to the recommendations made at the end of this report.</div

Lucía de Lammermoor

Empresa Juan A. PamiasFunció a 'beneficio con bandeja a favor de los empleados permanentes, porteros y acomodadoresIntèrprets : Joan Sutherland , Jaume AragallOrquestra del Gran Teatre del Liceu dirigida per Gianfranco RivoliRegidor d'escena : Pablo Civil ; Mestre de Cor : Ricardo Bottino ; Mestre de ball : Joan Magrinyà ; Mestre apuntador : Àngel Anglad

The Iowa Homemaker vol.28, no.8

Grapplers Provide Mat Thrill, John Marousek, page 3 Can Science and Religion Mix?, Barb Allen, Janet Sutherland, page 4 Teach Home Economics, Pat Close, page 7 It’s Merrill-Palmer, Peggy Krenek, page 8 Vicky Steps Out In Cotton, Jo Ann Breckenridge, page 11 What’s New In Home Economics, Peggy Krenek, page 12 Sight-seeing In Peiping, China, Joan Kelleher, page 14 Backstage At the Theatre Workshop, Frances Bosnak, page 18 Beware - Headaches, Margaret Wallace, page 21 Keeping Up With Today, Mary West, page 2

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa.

BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are relevant to protective immunity in high-endemic areas. METHODS: We analysed responses to 23 Mtb antigens in a total of 1247 subjects with different HIV and TB status across 5 geographically diverse sites in Africa (South Africa, The Gambia, Ethiopia, Malawi and Uganda). We used a 7-day whole blood assay followed by IFN-γ ELISA on the supernatants. Antigens included PPD, ESAT-6 and Ag85B (dominant antigens) together with novel resuscitation-promoting factors (rpf), reactivation proteins, latency (Mtb DosR regulon-encoded) antigens, starvation-induced antigens and secreted antigens. RESULTS: There was variation between sites in responses to the antigens, presumably due to underlying genetic and environmental differences. When results from all sites were combined, HIV- subjects with active TB showed significantly lower responses compared to both TST(-) and TST(+) contacts to latency antigens (Rv0569, Rv1733, Rv1735, Rv1737) and the rpf Rv0867; whilst responses to ESAT-6/CFP-10 fusion protein (EC), PPD, Rv2029, TB10.3, and TB10.4 were significantly higher in TST(+) contacts (LTBI) compared to TB and TST(-) contacts fewer differences were seen in subjects with HIV co-infection, with responses to the mitogen PHA significantly lower in subjects with active TB compared to those with LTBI and no difference with any antigen. CONCLUSIONS: Our multi-site study design for testing novel Mtb antigens revealed promising antigens for future vaccine development. The IFN-γ ELISA is a cheap and useful tool for screening potential antigenicity in subjects with different ethnic backgrounds and across a spectrum of TB and HIV infection states. Analysis of cytokines other than IFN-γ is currently on-going to determine correlates of protection, which may be useful for vaccine efficacy trials

Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial

BACKGROUND: New treatment options are needed for patients with multiple myeloma that is refractory to proteasome inhibitors and immunomodulatory drugs. We assessed daratumumab, a novel CD38-targeted monoclonal antibody, in patients with refractory multiple myeloma. METHODS: In this open-label, multicentre, phase 2 trial done in Canada, Spain, and the USA, patients (age ≥18 years) with multiple myeloma who were previously treated with at least three lines of therapy (including proteasome inhibitors and immunomodulatory drugs), or were refractory to both proteasome inhibitors and immunomodulatory drugs, were randomly allocated in a 1:1 ratio to receive intravenous daratumumab 8 mg/kg or 16 mg/kg in part 1 stage 1 of the study, to decide the dose for further assessment in part 2. Patients received 8 mg/kg every 4 weeks, or 16 mg/kg per week for 8 weeks (cycles 1 and 2), then every 2 weeks for 16 weeks (cycles 3-6), and then every 4 weeks thereafter (cycle 7 and higher). The allocation schedule was computer-generated and randomisation, with permuted blocks, was done centrally with an interactive web response system. In part 1 stage 2 and part 2, patients received 16 mg/kg dosed as in part 1 stage 1. The primary endpoint was overall response rate (partial response [PR] + very good PR + complete response [CR] + stringent CR). All patients who received at least one dose of daratumumab were included in the analysis. The trial is registered with ClinicalTrials.gov, number NCT01985126. FINDINGS: The study is ongoing. In part 1 stage 1 of the study, 18 patients were randomly allocated to the 8 mg/kg group and 16 to the 16 mg/kg group. Findings are reported for the 106 patients who received daratumumab 16 mg/kg in parts 1 and 2. Patients received a median of five previous lines of therapy (range 2-14). 85 (80%) patients had previously received autologous stem cell transplantation, 101 (95%) were refractory to the most recent proteasome inhibitors and immunomodulatory drugs used, and 103 (97%) were refractory to the last line of therapy. Overall responses were noted in 31 patients (29.2%, 95% CI 20.8-38.9)-three (2.8%, 0.6-8.0) had a stringent CR, ten (9.4%, 4.6-16.7) had a very good PR, and 18 (17.0%, 10.4-25.5) had a PR. The median time to first response was 1.0 month (range 0.9-5.6). Median duration of response was 7.4 months (95% CI 5.5-not estimable) and progression-free survival was 3.7 months (95% CI 2.8-4.6). The 12-month overall survival was 64.8% (95% CI 51.2-75.5) and, at a subsequent cutoff, median overall survival was 17.5 months (95% CI 13.7-not estimable). Daratumumab was well tolerated; fatigue (42 [40%] patients) and anaemia (35 [33%]) of any grade were the most common adverse events. No drug-related adverse events led to treatment discontinuation. INTERPRETATION: Daratumumab monotherapy showed encouraging efficacy in heavily pretreated and refractory patients with multiple myeloma, with a favourable safety profile in this population of patients. FUNDING: Janssen Research & Development

Application of a stochastic modeling to evaluate tuberculosis onset in patients treated with tumor necrosis factor inhibitors

In this manuscript we apply stochastic modeling to investigate the risk of reactivation of latent mycobacterial infections in patients undergoing treatment with tumor necrosis factor inhibitors. First, we review the perspective proposed by one of the authors in a previous work and which consists in predicting the occurrence of reactivation of latent tuberculosis infection or newly acquired tuberculosis during treatment; this is based on variational procedures on a simple set of parameters (e.g. rate of reactivation of a latent infection). Then, we develop a full analytical study of this approach through a Markov chain analysis and we find an exact solution for the temporal evolution of the number of cases of tuberculosis infection (re)activation. The analytical solution is compared with Monte Carlo simulations and with experimental data, showing overall excellent agreement. The generality of this theoretical framework allows to investigate also the case of non-tuberculous mycobacteria infections; in particular, we show that reactivation in that context plays a minor role. This may suggest that, while the screening for tuberculous is necessary prior to initiating biologics, when considering non-tuberculous mycobacteria only a watchful monitoring during the treatment is recommended. The framework outlined in this paper is quite general and could be extremely promising in further researches on drug-related adverse events.Comment: 26 pages, 7 figure

Kin discrimination and possible cryptic species in the social amoeba Polysphondylium violaceum

Abstract Background The genetic diversity of many protists is unknown. The differences that result from this diversity can be important in interactions among individuals. The social amoeba Polysphondylium violaceum, which is a member of the Dictyostelia, has a social stage where individual amoebae aggregate together to form a multicellular fruiting body with dead stalk cells and live spores. Individuals can either cooperate with amoebae from the same clone, or sort to form clonal fruiting bodies. In this study we look at genetic diversity in P. violaceum and at how this diversity impacts social behavior. Results The phylogeny of the ribosomal DNA sequence (17S to 5.8S region) shows that P. violaceum is made up of at least two groups. Mating compatibility is more common between clones from the same phylogenetic group, though matings between clones from different phylogenetic groups sometimes occurred. P. violaceum clones are more likely to form clonal fruiting bodies when they are mixed with clones from a different group than when they are mixed with a clone of the same group. Conclusion Both the phylogenetic and mating analyses suggest the possibility of cryptic species in P. violaceum. The level of divergence found within P. violaceum is comparable to the divergence between sibling species in other dictyostelids. Both major groups A/B and C/D/E/F show kin discrimination, which elevates relatedness within fruiting bodies but not to the level of clonality. The diminished cooperation in mixes between groups suggests that the level of genetic variation between individuals influences the extent of their cooperation

Cyclophilin B Interacts with Sodium-Potassium ATPase and Is Required for Pump Activity in Proximal Tubule Cells of the Kidney

Cyclophilins (Cyps), the intracellular receptors for Cyclosporine A (CsA), are responsible for peptidyl-prolyl cis-trans isomerisation and for chaperoning several membrane proteins. Those functions are inhibited upon CsA binding. Albeit its great benefits as immunosuppressant, the use of CsA has been limited by undesirable nephrotoxic effects, including sodium retention, hypertension, hyperkalemia, interstial fibrosis and progressive renal failure in transplant recipients. In this report, we focused on the identification of novel CypB-interacting proteins to understand the role of CypB in kidney function and, in turn, to gain further insight into the molecular mechanisms of CsA-induced toxicity. By means of yeast two-hybrid screens with human kidney cDNA, we discovered a novel interaction between CypB and the membrane Na/K-ATPase β1 subunit protein (Na/K-β1) that was confirmed by pull-down, co-immunoprecipitation and confocal microscopy, in proximal tubule-derived HK-2 cells. The Na/K-ATPase pump, a key plasma membrane transporter, is responsible for maintenance of electrical Na+ and K+ gradients across the membrane. We showed that CypB silencing produced similar effects on Na/K-ATPase activity than CsA treatment in HK-2 cells. It was also observed an enrichment of both alpha and beta subunits in the ER, what suggested a possible failure on the maturation and routing of the pump from this compartment towards the plasma membrane. These data indicate that CypB through its interaction with Na/K-β1 might regulate maturation and trafficking of the pump through the secretory pathway, offering new insights into the relationship between cyclophilins and the nephrotoxic effects of CsA

Egyenlő bánásmód és esélyegyenlőség a foglalkoztatáspolitikában

Az elektronikus kiadvány a TÁMOP‐5.4.4‐09/1/C‐2009‐0001 „Képzésfejlesztés az összetart(oz)ásért” projekt keretében készült